Effect of Prostaglandin E 1 on the Pulmonary Vascular Response to Endotoxin 1

Abstract

Summary

Endotoxin causes an increase in vascular resistance and the release of some lysosomal enzymes in the circulation of the isolated lobe of the dog lung perfused in situ. These effects of endotoxin were prevented by the administration of PGE₁. When PGE₁ was infused after endotoxin was given, the increase in the pulmonary perfusion pressure was greatly reduced. Thus similar to the previously tested anti-inflammatory drugs, PGE₁ can block some of the effects of endotoxin in the circulation.

We are grateful for the skillful technical assistance of Mrs. P. Downs. Prostaglandin was kindly supplied by the Upjohn Company and by Dr. J. Nakano of O. U. Medical Center.