The Production of Intestinal Fluid by Cholera Toxin in the Rat 1

Abstract

Summary

The intestine of the rat can be used as a cholera model. The amount of fluid production in in vivo intestinal loops was dependent on the amount of toxin present. With increased fluid production HCO₃ and Cl concentrations approached those in plasma. Acetazolamide did not minimize fluid production while it was uncertain whether cycloheximide had any effect. In in vitro everted sacs, prepared from intestines which were secreting fluid in response to cholera toxin in vivo, there was a net transport of fluid from the mucosal to serosal side.