Abstract
Summary
Fibroblasts readily adhere to polymerizing fibrin, but not to fibrinogen or fully polymerized fibrin. Conditions for optimal interaction are similar to those known for the platelet-fibrin interaction. Fibroblasts retract fibrin formed by thrombin but not by reptilase. Fibrin retraction induced by fibroblasts is inhibited by agents inhibiting clot retraction induced by platelets.
We thank Dr. L. Prevec for generous supplies of fibroblasts and Messrs. A. F. Senyi, K. L. Wong and T. Bistricki for skilled technical assistance.
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