The rôle of hepatic tissue in anaphylaxis

Abstract

If 0.25 per cent. goat serum in 50 per cent. defibrinated normal blood is repeatedly perfused through the liver of a normal guinea pig, a slight reduction in the toxicity of the perfusion fluid is usually observed, on subsequent tests with isolated anaphylactic lungs. In no case, however, is the reduction in toxicity sufficient to prevent the anaphylactic reaction in these lungs.

If the liver of an anaphylactic guinea pig is similarly perfused, the perfusion fluid usually becomes almost completely non-toxic for anaphylactic lungs.

This reduction in toxicity is not accompanied by a measurable decrease in the amount of goat protein in the perfusion fluid, as determined by a subsequent titration with a specific precipitin.