Abstract
Summary
Initial inhibition of label accumulation into RNA of rhinovirus infected cells occurs 5 hr postinfection when viral RNA synthesis is at a maximum. Infection lowers the level of label accumulation into protein with maximum inhibition occurring late in the cycle. Actinomycin D does not significantly affect protein synthesis in infected cells. These results support the hypothesis that two separate functions are responsible for inhibition of host RNA and protein synthesis.
This investigation was supported by Research Contract NIH 69-2062 from the National Institute for Allergy and Infectious Diseases, and by U.S. Public Health Service General Research Support Grants 22-14-54 and 22-15-74 from the Children's Hospital Research Foundation. Miss Judy Halstead provided valuable technical assistance.
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