Abstract
Summary
In a study of the effects of anti-lymphocytic serum (ALS), azathioprine, and prednisone on the acceptance-rates of three mouse and two rat tumors in allogeneic hosts, marked increases in average tumor acceptance rates, and usually but not always in terminal tumor weights, were observed following treatment with ALS alone, or in combination with either or both or the other two agents. The technique of allogeneic tumor grafts offers a simple semiquantitative procedure to evaluate the effect of drugs, sera, and related agents on the immunocompetence of animal systems, especially in relation to control mechanisms of tumor induction and development.
We thank Dr. Arthur E. Bogden, Mason Research Institute, for the prostatic carcinoma 11095 and mammary adenocarcinoma 1/C; Dr. Harry B. Wood, Cancer Chemotherapy National Service Center, National Cancer Institute, for supplying azathioprine and prednisone; and Mr. Charles Kelley and Mr. Donald Dykes for their technical assistance.
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