Abstract
Summary
Early manifestation of antinuclear antibodies (ANA) in the plasma of NZB mice was significantly depressed by twice weekly injection of 20 mg/kg body weight cytoxan from the age of 9 days. Single injection of 75 mg/kg at 6 or at 13 days of age was ineffective in this regard. Similarly, ongoing ANA responses in 4-month-old NZB mice were undiminished by single injection of 180 or 300 mg/kg of cytoxan. A course of administration of 160 μg of poly I·C followed 24 hr later by 75 mg of cytoxan was repeated three times during a period of 56 days in an attempt to induce tolerance in 2-month-old ANA positive mice. Attenuation of ANA response was demonstrable 2 weeks after initiation of treatment, but was not observed at later times during the study, conceivably a consequence of the anti-DNA activity of the antinuclear antibody assayed.
We thank Mrs. Sherrie Fitzgerald for her technical assistance.
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