Abstract
Summary
Body weights and weights of major salivary glands and pancreas of mice given sublethal doses of 5-FUR were studied after pilocarpine or poly A:U injection. Body weights showed a significant decrease during the first 5 days after 5-FUR alone, while in the same period the glandular weights increased in all 4 organs. Injections of pilocarpine prior to sacrifice abolished the increase in glandular weights in salivary glands, but the pancreas failed to respond. This increase in organ weight was thought to be due to the inability of the organs to release synthesized secretory products. An injection of poly A:U 24 hr prior to sacrifice produced a uniform release of secretory products during the recovery phase in all of the organs studied. Such effect was notably absent on day 5 when the 5-FUR effect was at a maxium. It is concluded that the introduction of synthetic poly A:U might improve the recovery processes following nucleotide insult, as well as trigger release mechanisms in a manner which is different from that of pilocarpine.
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