Effect of Prostaglandins E 1 and A 1 on the Gastric Circulation in Dogs 1

Abstract

Summary

The effect of intravenous and intraarterial injections of PGE₁ and PGA₁ on the gastric peripheral vascular beds was studied in anesthetized dogs, in which the total gastric arterial system was perfused at a constant rate of blood flow by a Sigmamotor pump. By both routes of administration, both PGE₁ and PGA₁ decreased the gastric arterial perfusion pressure and the gastric peripheral vascular resistance, while the gastric venous pressure remained essentially unchanged. This study indicates that PGE₁ and PGA₁ are potent vasodilators on the gastric circulation in the dog.

The authors are grateful to Dr. J. Pike of the Upjohn Co., Kalamazoo, MI, and Dr. H. Strade, of the Organon Inc., West Orange, NJ for their generous supplies of PGE₁ and PGA₁ and Liquaemin (sodium heparin), respectively.