Abstract
Summary
Elevations of bradykinin levels in blood were regularly induced in normal subjects by intravenously administered bacterial endotoxin. Bradykinin was detected as early as 30 min after injection, was maximal by 1 hr and thereafter declined. The magnitude and timing of kinin formation coincided with granulocytopenia and preceded fever and granulocytosis. No increase in blood bradykinin levels were observed after the administration of a steroid pyrogen, etiocholanolone. The data are consistent with the contention that kinin may contribute to the biologic events accompanying endotoxemia in man.
The authors thank Drs. D. Alling and M. Webster for valuable assistance and advice.
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