Abstract
Summary
Mice pretreated with complete Freund's adjuvant had an enhanced resistance to autochthonous and transplanted tumors. Delayed time to death and/or increased survival was noted in CFA pretreated mice grafted intraperitoneally with Sarcoma 180, leukemia L1210, or Friend leukemia spleen cells. In addition, CFA pretreatment caused a statistically significant delay in spontaneous mammary tumor development in C3H/HeJ mice and spontaneous leukemia in AKR mice. We propose that host resistance to intracellular infectious agents and neoplasia is related in a fundamental way and the activated macrophage is a common effector arm for expression of this resistance. It is also suggested that a nonimmunologic growth control mechanism such as we have described offers a rapid acting homeostatic process for destruction of cells with abnormal growth properties in vivo.
Get full access to this article
View all access options for this article.