Abstract
Summary
Femoral bone marrow cellulari–ty, CFU concentration, and CFU content were markedly subnormal in allogeneic radiation chimeras that had been produced with bone marrow cells from adult donors.
2. Marrow cellularity was restored to normal within 3 weeks when liver or liver plus thymus from fetal donors was the tissue transplanted.
3. In chimeras produced with fetal cell transplants, marrow CFU increased at a slower rate than did differentiated marrow cells. However, at 77 ± 7 days, chimeras produced with fetal liver plus fetal thymus cells had normal numbers of femoral CFU and this level was significantly higher than in chimeras produced with fetal liver without thymus cells.
4. Hematopoietic repopulation of allogeneic radiation chimeras using combined fetal liver and thymus cell transplants was equal or superior to that achieved with fetal liver alone or adult bone marrow despite the fact that with the latter tissues 2 to 5 times as many hematopoietic stem cells had been transplanted.
Expert technical assistance was provided by Miss Brigid M. Finnegan, Mrs. Alice C. Grady, and Mrs. Evangeline R. Reynolds.
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