Abstract
Summary
Adult outbred guinea pigs were sensitized, without added adjuvants, with a single dose of homogenates prepared from homologous testis previously subjected to thermal injury in vivo or in vitro. It was observed: (A) With exception of positive results obtained with the sperm immobilizing test, no antisperm antibodies of anaphylactic, precipitating, and complement–fixing types were induced. (B) Delayed hypersensitivity, as revealed by skin test and inhibition of macrophage migration, appeared positive in parallel with testicular and epididymal damage similar to the so–called allergic orchitis. (C) Only homogenate prepared with acute thermal damaged testis was able to provoke such a response but not that prepared with testis having thermal chronic lesions. (D) Homogenates from normal adult testis or prepared with kidney having acute thermal nephritis gave negative results.
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