Abstract
Summary
The inhibitory sensitivities and substrate preferences of dog erythrocyte, leukocyte, thrombocyte, and liver subcellular fraction acid phosphatases were determined and compared to those of the serum acid phosphatase appearing after long periods of hepatic inflow stasis. This postschemic acid phosphatase is inhibited moderately by tartaric acid and strongly by copper sulfate and the ratio of activities with PNPP to that of ANP shows values around seven. These characteristics are similar to those of platelet, white blood cell, and liver microsomal-soluble supernatant fraction acid phosphatases. Since there is extensive leakage of other cytoplasmic enzymes into circulation following liver ischemia it seems likely that cytoplasmic nonlysosomal acid phosphatase contributes considerably to the postischemic serum acid phosphatase activity.
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