Abstract
Summary
The effects of a 48-hr intraduodenal perfusion of electrolyte solution, 50 mM 3-0-methyl glucose (3-0-MG), glucose, or fructose, 1.39 M glucose or fructose on the subsequent absorption of 3-0-MG were studied in 20-cm segments of rat jejenum perfused extracorporeally through the superior mesenteric artery. The feeding of glucose or fructose enhanced the transport of 3-0-MG while 3-0-MG itself had no effect. This adaptive change was independent of substrate concentration, calories fed, weight loss, bowel wall glucose content, and hexokinase activity of mucosal scrapings.
The authors thank Doctor M. Strobel of the University of Montreal for assistance with the statistical analyses.
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