Abstract
Summary
A 12-fold increase in sodium excretion occurred in hypophysectomized or adrenalectomized water-loaded rats after ip injection of 10 μg of α-MSH compared with the low sodium excretion in saline-injected control rats. Potassium excretion also increased significantly but to a much lesser degree. There was no change in the urine output. The results indicate that neither the pituitary gland nor the adrenals mediate the natriuresis produced by MSH.
The authors thank Miss Susan Willsey for her excellent technical assistance in these studies.
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