Abstract
Summary
Serum LH and FSH were determined by radioimmunoassay in 4-day cyclic rats at approximately 24, 29 and 47 hr after a single injection of EB. Ovulation was determined by the presence of ova in the oviduct 48 hr after EB. Serum LH was elevated 24 and 29 hr and drastically reduced at 47 hr after EB. Serum FSH showed only a slight increase at 29 hr after EB. It is suggested that a surge of ovulatory gonadotropin secretion, primarily LH, occurs 24 hr ahead of schedule in EB-treated 4-day cyclic rats.
This work was supported by NIH Grant HD-03736, The Ford Foundation and The Bing Fund.
We are grateful to The National Institute of Arthritis and Metabolic Diseases, Rat Pituitary Hormone Program for the radioimmunoassay kits for LH and FSH.
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