Abstract
Summary
The physical stability of the potent procoagulant(s) synthesized by cultured fibroblasts was studied. Variation in stability of procoagulant under the influence of heat, sonication, and freeze-thawing suggested that multiple procoagulants account for activity observed in specific assays for the first-stage coagulation factors (VIII, IX, XI, XII) rather than a single procoagulant (such as tissue factor). The stability of brain tissue factor most closely resembled activity observed in the factor XII assay. Stability patterns observed in assays for factor VIII and XI were similar.
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