Abstract
Summary
Wide variations in calcium concentrations were induced in arterial blood perfusing isolated dog adrenals. During NaEDTA, calcium fell without consistent change in 17-OH corticosteroid secretion. During calcium repletion and hypercalcemia secretion, rates of 17-OH corticosteroids rose significantly in both hypo-physectomized and nonhypophysectomized dogs. Acute calcium administration, without prior Na EDTA, also produced increased 17-OH corticosteroid secretion. However, no close correlation between calcium concentrations and 17-OH corticosteroid secretion was observed. Hypercalcemia appears to stimulate glucocorticoid secretion in the whole adrenal gland in situ.
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