Abstract
Summary
Estrogen-primed rat uteri isolated in a Krebs-Ringer bicarbonate bath containing either glucose, mannose, galactose, pyruvate, or lactate had levels of phosphorylase a activity significantly lower than in uteri in the bath without these substrates. Fructose, arabinose, and sucrose had no effect on the activity of the enzyme. It appears that the substrate must be capable of complete metabolism by the uterine cells in order to effect the levels of phosphorylase a activity. Others report that in the isolated diaphragm, only glucose, among these sugars tested, has an inhibitory effect on the enzyme activity.
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