Abstract
Summary
The influence of norethynodrel on the sialic acid content of the submandibular gland was studied. Seventy days after ovariectomy, the concentration of sialic acid in the gland was reduced greatly. Administration of norethynodrel at daily doses of 0.075 and 3 mg for 10 days to intact and ovariectomized rats increased the concentration and total amount of sialic acid in the gland, the response being greater at the higher dose. The evidence indicates that (a) the sialic acid content of the submandibular glands is dependent on ovarian secretions, and (b) norethynodrel has the capacity to increase the content of sialic acid in the submandibular gland, this response most likely being due to the estrogenic property of norethynodrel.
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