Abstract
Summary
Binding of labeled uric acid to serum proteins of eleven animal species was studied using an equilibrium dialysis system. Significant differences were found among species with serum of man, rhesus monkey, rabbit, rat, guinea pig, and chicken demonstrating binding but with little or no binding found in serum of other animals studied. The physiologic significance of these variations is uncertain since they do not correlate with known differences in uric acid excretion by these animals, and binding is demonstrated only at low temperature in hypotonic buffers. The findings do indicate significant differences in the binding site on albumin.
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