Abstract
Summary
Passive administration of hyperimmune antiserum into syngenic NZB recipients produced a marked depression of spleen anti-SRBC plaque formation. This antiserum was equally effective in BALB/c mice, depression persisting in both strains for as long as 2 months following ip injection of 0.02 ml serum. These observations would suggest that the immunological hyperresponsiveness previously described for NZB strain mice does not derive from a deficiency in 7S antibody-mediated feedback inhibition of the immune response. Transfer of serum from 1-year-old Coomb's positive mice and from 7-month-old ANA-positive animals into preautoimmune baby NZB recipients was without effect on the subsequent course of development of antinuclear antibody and of Coomb's reactivity. The inability to alter the course of autoantibody formation by such passive transfer of sera may involve a number of factors which are discussed.
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