Abstract
Summary
Removal of avian leukosis viruses (ALV) which have contaminated the yellow fever (YF) 17D vaccine since its development in the middle 1940's, had no effect upon the reactogenicity and antigenicity of this vaccine in man. From results of plaque neutralization (PN) tests, the high degree of antigenicity of the 17D vaccine was confirmed.
Preexisting yellow fever antibody appeared to interfere with the antibody response to YF vaccine. Administration of YF vaccine did elicit antibodies capable of cross-reacting with West Nile, and less so with Langat, arbovirus antigens.
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