Abstract
Summary
The effects of dietary calcium [0.1% (low) or 0.6% (normal)] and phosphorus [0.4% (normal) or 0.9% (high)] on 54Mn metabolism were determined following single ip or oral dosing in weanling rats. Rats receiving the low calcium diet excreted much more 54Mn from both ip and oral doses via feces and urine, and their tissues retained much less. Within each dietary calcium level, urinary excretion of ip administered 54Mn was far less on the high phosphorus diet. With orally administered 54Mn, high dietary phosphorus increased 54Mn tissue concentrations. These results show that low dietary calcium has a major effect on manganese metabolism at the tissue level as well as within the gut.
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