Abstract
Summary
Hyperglycemia and hypolipemia were observed in rats after the injection of sodium pentobarbital (Nembutal). The observed changes were independent of whether the blood was collected by decapitation or by needle puncture of the aorta. The hyperglycemic response was caused by two factors, the stress of the injection per se and the pharmacological action of the drug. Hyperlipemia was observed at 5 min postinjection; however, pentobarbital decreased plasma free fatty acids by 15 min postinjection. Both the hyperglycemia and hypolipemia responses were dose dependent.
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