Abstract
Summary
The effect of acetylcholine on the beating rate of single chick embryo heart cells cultured from 8 to 10 day ventricles was determined using a new television monitor optical system. Acetylcholine had a clear negative chronotropic effect on these cells, with a threshold at 10-8-10-7 g/ml. The slowing in beating rate after the addition of acetylcholine was reversible, and was not associated with any detectable change in the inotropic state of the cells. These findings are consistent with the effect of acetylcholine on non-cultural chick embryo ventricular tissue of the same age.
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