Abstract
Summary
L cell monolayers and mice were exposed to infectious and to inactivated Colorado tick fever virus. Ultraviolet irradiation of the virus was able to increase the rate of appearance of interferon in both in vitro and in vivo. Heat- and pH-inactivated virus failed to evoke an interferon response in both systems. It is proposed that UV irradiation permits faster release of the CTF virus RNA while heat and pH inactivation prevent this release.
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