Abstract
Summary
Rabbits immunized with the double-stranded polynucleotide complex formed by polyinosinic and polycytidylic acid coupled with methylated bovine albumin and emulsified in Freund's complete adjuvant failed to produce interferon after intravenous injection of this inducer. Suppression of interferon production also occurred when immune rabbits were injected with an RNase-resistant form of the inducer obtained by complexing it with DEAE-dextran. This result indicates that increased serum RNase was not responsible for the inhibitory activity. In rabbit kidney cell cultures, sera obtained from immunized rabbits suppressed the antiviral activity of the inducers. This effect was associated with the immunoglobulin serum fraction despite a strong decrease of RNase activity in this fraction.
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