Abstract
Summary
The effects of hemorrhagic, endotoxin, and catecholamine shocks on canine gracilis muscle vascular resistance were determined. Endotoxin produced a transient increase in vascular resistance followed by a steady decline toward preendotoxin values. Norepinephrine produced a transient decrease in vascular resistance followed by a sustained increase in resistance. Slow hemorrhage (60% blood volume depletion) produced sustained, marked increases in vascular resistance; whereas rapid hemorrhage (60% blood volume depletion) produced only transient increases in vascular resistance, which soon waned and fell to prehemorrhage levels. Most of the animals subjected to rapid hemorrhage died after 2 hr despite partial transfusion of the shed blood when systemic pressure fell below 30 mm Hg. Control animals displayed only minor alterations in the variables under study. These data demonstrate that the response of skeletal muscle vasculature to circulatory shock depends on the type of shock, and also on the severity of a given shock.
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