Abstract
Summary
Since previous studies have demonstrated a profound suppression of the renin—aldosterone system during water immersion in man, the specificity of this suppression of adrenal function was assessed. Urinary aldosterone and 17-OHCS release were simultaneously measured in six normal subjects studied during a control period and during water immersion under identical conditions of diet, posture, and time of day. There was a marked decrease in aldosterone excretion during immersion and during the initial 2 hr of recovery (p<.005). In contrast, neither urinary nor plasma 17-OHCS was significantly altered by immersion. The dissociation observed between the effects of immersion on aldosterone and 17-OHCS activity suggests that the suppression of the reninaldosterone system is selective and further supports the concept of independent control of adrenal mineralocorticoid and glucocorticoid secretion.
Get full access to this article
View all access options for this article.