Abstract
Summary
Two preparations of Gross passage A virus (one from leukemic tissues and the other from cell-free peritoneal fluid from mice bearing transplantable Gross lymphoma in the ascites form) were used to compare the effectiveness of the intrathymic route of injection with that of the intraperitoneal route. With both preparations, the intrathymic route of inoculation produced a shorter latent period and a higher incidence of leukemia than did the intraperitoneal route. These findings further support the hypothesis that the thymus is a site of primary virus-cell interaction during leukemogenesis.
Intraperitoneal injection of virus from peritoneal fluid was more effective in leukemogenesis than similarly administered virus derived from leukemic tssues. Several hypotheses are suggested to explain this phenomenon. It could be the result of the virus titer or a heightened infectivity of the virus in the ascites form. It might also result from the combination of the virus with a helper virus or tissue components that foster infectivity. Or, perhaps, some transport mechanism reflecting a recognition phenomenon is involved.
Get full access to this article
View all access options for this article.