Abstract
Summary
Adult BALB/c mice treated monthly subcutaneously with 0.25 mg estradiol benzoate, had a high incidence of thymic lymphomas and more so in males than in females.
Administering of syngeneic spleen and bone marrow cells to estrogenized mice (i) protected against development of thymic lymphomas; (ii) increased the incidence of spleen amyloidosis; and (iii) was without influence on development of thymic cysts and testicular tumors.
Blood lymphocytes from estrogenized mice reacted normally to phytohemagglutinin, but the mice had a prolonged rejection time of allogeneic skin graft.
Spontaneous thymoma development in AKA mice was not influenced by grafting syngeneic cells.
Thymoma and spleen amyloidosis occurred as mutually exclusive qualities in both BALB/c and AKA mice.
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