Abstract
Summary
When fed with 2 or 4% cholestyramine, 0.5 and 1.0% dietary taurine increased fecal bile salt excretion by 44 to 56% in rats and by as much as 80% in hamsters. Taurine also increased bile salt excretion 30-44% in rats fed 0.07-1.68% cholestyramine. Dietary taurine increased the percentage of gallbladder bile salts conjugated with taurine in hamsters fed cholestyramine. These findings are consistent with in vitro findings that cholestyramine has a greater affinity for taurine-conjugated bile salts than for the corresponding glycine conjugates, and may provide a feasible means of improving the in vivo efficiency of the resin.
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