Abstract
Summary
Binding of polycyclic aromatic hydrocarbons to cellular macromolecules of the rat mammary gland in vivo was studied. The carcinogen 7,12-dimethylbenz[α]anthracene (DMBA) binds covalently to both DNA and cytoplasmic soluble protein. The binding of DMBA to cytoplasmic protein, however, is significantly greater than to DNA. Binding of DMBA to other macromolecular fractions is minimal. The noncarcinogen anthracene binds covalently to protein but forms a hydrophobic bond with DNA.
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