Abstract
Summary
Bone marrow cells of DBA/2 mice became histoincompatible to irradiated (BALB/c X DBA/2)F1 and (C57BL/6 × DBA/2)F1 hybrids a few hours after infection with Friend leukemia virus (FLV). This alteration was attributed to enhanced expression of Hybrid histocompatibility (Hh) gene(s), i.e., to more effective immunogenicity of the parental-specific alloantigens specified by Hh gene(s). The viral effect required live virions since it was abolished by inactivation of FLV with beta-propiolactone.
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