Abstract
Summary
A relationship has been noted between the antitumor activity of H4HF and its effect on incorporation of formate and orotate into DNA of organs of mice bearing advanced methotrexate-sensitive (L1210) and -resistant (L1210/FR-8) leukemia after daily treatment with H4HF for 4 days. Both formate and orotate uptake into DNA was markedly inhibited in organs of mice bearing L1210/FR-8 leukemia, but not in mice bearing L1210 leukemia. Single doses did not cause demonstrable inhibition of DNA synthesis in organs of mice bearing either of the tumor lines.
Get full access to this article
View all access options for this article.