Norepinephrine and Phenoxybenzamine Redistribution of Dog Forelimb Blood Flow and Volume 1

Abstract

Summary

Dog forelimbs were perfused under constant blood flow conditions. Norepinephrine significantly increased blood flow resistance and decreased total and active vascular volumes. ⁸⁶Rb recovery was increased. Phenoxybenzamine returned the resistance to control without changing total vascular volume or red cells-⁵¹Cr volume. However, albumin-¹³I space was increased with no change in ⁸⁶Rb recovery. Norepinephrine caused a reduction in capillary flow with redistribution of flow to shunt vessels. Alpha blockade allowed opening of circulatory areas constructed at least in part of nonexchange vessels.