Abstract
Summary
The new alpha adrenergic antagonist, WR-2823, causes epinephrine reversal of blood pressure in the anesthetized dog. The drug attenuates but does not reverse the mesenteric vasoconstrictor effects of norepinephrine and epinephrine. WR-2823 does cause phenylephrine reversal of mesenteric blood flow. Addition of beta adrenergic receptor blockade restores the responses of the mesenteric circulation to all four adrenergic agonists to that observed prior to treatment with WR-2823.
Get full access to this article
View all access options for this article.