Abstract
Summary
Vibrio cholerae neuraminidase (VCN) does not lyse mouse lymphoid cells at any concentration up to 250 units/ml/5 × 106 cells. VCN treatment of C3H/HeJ lymphoid cells increases their susceptibility to lysis with C57 anti-C3H serum and complement. It does not, however, increase the capacity of these cells to absorb C57 anti-C3H complement-fixing antibody. Thus, neither the increased susceptibility to lysis nor the increased allogeneic immunogenicity of VCN-treated lymphoid cells is due to an unmasking of more allogeneic antigens on the cell surface.
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