Abstract
Summary
Hypochromic microcytic anemia is produced in rats when injected with acetoacetate (20 mg/100 g) for 90 days. There was a moderate fall in erythrocyte counts, packed cell volume, and hemoglobin levels following the injections of acetoacetate. The anemia induced was most probably due to the deficiency of iron, as well as its malutilization for hemoglobin synthesis. The decrease in hemoglobin synthesis was attributed to multiple deficiency of B vitamins, specially pyridoxine, whereas defect in iron transport and utilization could be due to deficiency of ascorbic acid and glutathione.
Get full access to this article
View all access options for this article.