Abstract
Summary
Endotoxin and histamine injections produced similar hemodynamic and physiologic changes, but these similarities are not equated to tissue damage or changes in cellular permeability, as shown by the activity of serum enzymes. Endotoxin causes extensive tissue damage by the third hour as demonstrated by high levels of lactic dehydrogenase, isocitric dehydrogenase, the transaminases, and creatine phosphokinase, and specific tissue damage as demonstrated by isozyme determinations. Histamine produced only transient elevation in creatine phosphokinase and the transaminases, which did not differ significantly from the saline controls.
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