Effects of p -Chlorophenoxyisobutyric Acid (CPIB) on Adipose Tissue Triglycerides Synthesis,Lipogenesis,and Some Related Enzymes 1

Abstract

Summary

The addition of 0.25% CPIB to a glycerol-lard diet fed to rats resulted in increased adipose tissue activities of triglyceride synthesizing enzymes, hexose monophosphate shunt dehydrogenases, and NADP-malic enzyme. Incorporation of ¹⁴C-glucose and ³H from water into long chain fatty acids by fat pads in vitro was also greater in CPIB-treated rats. The drug had only small or no such effects when added to a fat-free high sucrose diet.