Abstract
Summary
A transplanted stomach tumor (CBA 2663) caused a striking decrease in total body lipid content and suppression of food intake while growing in GTG-obese and genetically “yellow obese” mice. Nonobese mice bearing the same tumor showed a comparable percentage of lipid depletion, but food intake decreased only as the host became moribund. The rate of lipid depletion was greater in the GTG-obese compared to nonobese hosts on a per gram tumor weight basis. Lipid depletion proceeded at a faster rate in GTG-obese (CBA × C57Bl)F1 hybrids bearing the CBA tumor compared to a sarcoma (C57B114) both having the same growth rate. Food intake was also rapidly depressed in the F1 hybrids bearing the CBA tumor, but not in those with the C57Bl sarcoma. It is suggested that the CBA tumor has some unique biological characteristics, which facilitates mobilization of body lipid stores which in turn influences food intake.
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