Abstract
Summary
Treatment of rat kidney cortex slices with phospholipase C at high concentrations leads to increased total tissue water, inulin space, reduced a-aminoisobutyric acid (AIB) uptake as well as increased efflux. These observations are concluded to represent alterations in permeability characteristics of the slices. Treatment with doses of phospholipase C that cause no alteration in distribution of water or sodium is associated with reduction in potassium content of slices and reduction in AIB accumulation which is not associated with altered efflux. The relationships of the role of phospholipids to renal tubule transport systems for monovalent cations and amino acids are discussed.
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