Abstract
Summary
In the presence of porcine tissue plasminogen activator, fibrinolysis is greatly enhanced in comparison with fibrinogenolysis. In contrast, other activators (UK, SK-activator) and plasmin showed no, or moderate, differences between lysis of fibrinogen and fibrin. The enhanced tissue activator effect is related to the activation of plasminogen. The observations add a specific mechanism of enhancement of fibrinolysis by tissue activator to that caused by the influence of inhibitors. The process may help to enhance localized fibrinolysis following tissue injury without affecting fibrinogen.
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