Abstract
Summary and Discussion
U-29,409 (2,3-dihydro- (1-naphthyl)-4-(1H)-quinazolinone), a male antispermatogenic drug, exerts anti-arthritic effects in rats similar to those elicited by Cytoxan. However, it is less effective than the latter. Laboratory screening tests fail to show that U-29,409 has acute anti-inflammatory effects when given as a single dose or for 1 week prior to performing acute inflammatory reactions. In combination with Cytoxan, U-29,409 appears to exert a synergistic inhibitory effect on developing arthritis. Neither Cytoxan nor U-29,409 appears to exert significant inhibitory effects in rats with established disease. Both drugs, unlike nonsteroidal anti-inflammatory drugs, fail to display inhibitory effects in yeast-induced fever of rats.
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