Abstract
Summary
These data show that the pulmonary vasopressor response to perfusates of acidified plasma or whole blood fractions suspended in LMD is directly related to the platelet concentration of the perfusate. The pressor response is not directly related to local vascular effects of lowered perfusate pH within the range 7.40-6.35. This response appears to be mediated by the release of vasoactive substances from platelets at the site of acid infusion. It is suggested that the effect of an increase in hydrogen ion concentration on platelets causes direct physi-cochemical alterations which activate and release pulmonary vasopressor materials.
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