Abstract
Summary
Using stimulated rat peritoneal macrophages, a specific antimacrophage antibody has been prepared in rabbits. Immunofluorescent studies reveal that the antigen(s) is present in free, and absent in fixed, phagocytic cells in the rat. The antigen(s) has also been identified in free macrophages of guinea pigs, mice, and rabbits. Fixed macrophages in the same animal species are consistently negative. The results indicate that free macrophages are antigenically different from fixed phagocytic cells, and that the antigen(s) lacks species specificity.
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