Abstract
Summary
Renal excretory patterns of sodium, potassium and water were studied in unoperated and hypophysectomized rats as functions of pretreatment with d-aldosterone and actinomycin D. Observations included:
1. A GFR-depressing function of aldosterone in the sodium-depleted hypophysectomized rat.
2. A glucocorticoid-like response to aldosterone in the sodium-depleted hypophysectomized rat.
3. A GFR-stimulating function of actinomycin D, which was reversible by a priori but not by a posteriori administration of aldosterone.
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